Laboratory of Genome Integrity

Research in the LIG focuses on various mechanistic aspects of the DNA damage response and DNA repair pathways. Both pathways play a key role in the onset and progress of cancer and thus represent ideal targets for novel anti-cancer drugs. In addition we endeavor to understand how elevated replication stress in rapidly growing pre-cancerous and cancerous cells affects the progression of the disease. We would also like to understand in detail how the cell copes with replication stress at the molecular level.

Our long term goal is to set up specific DDR response based high throughput screens capable of assessing the effect of different compounds and environmental conditions on DNA integrity in human cells. In our research we employ state-of-the-art equipment including the Carl Zeiss Super-resolution and Spinning Disc microscopic systems.